Efficacy of Povidone Iodine in Treatment of Active Chronic Suppurative Otitis Media
This is a double-blind prospective study done in Basra, Iraq, from February 1 to October 31, 2005.
Forty-eight patients with active chronic suppurative otitis media (CSOM)
were included in this study. Full histories were obtained. Otological examinations and ear swabs for culture were done. Pure tone audiometry (PTA) was performed before and two weeks after treatment. All the patients studied were treated systemically by an appropriate dose of amoxicillin.
The most common isolated organism was staphylococcus aureus (25%), followed by pseudomonas aeroginosa (18.8%) and streptococcus pneumoniae (18.8%).
Povidone iodine (betadine) 5% solution, neomycin dexamethasone (neodexone) drops, and normal saline 0.9% were used as local therapy (ear drops) randomly for three equally divided groups of patients.
Complete improvement occurred in 81% of the patients using povidone iodine ear drops, compared with 69% using neomycin-dexamethasone drops and only 25% using normal saline drops. Further, improvement using povidone iodine occurred earlier than improvement using neomycin-dexamethasone and normal saline ear drops.
No complications were detected as a result of any of the above treatment modalities.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).