The ENCODE Project: Deciphering the Human Genome’s Rosetta Stone
The successful completion of the Encyclopedia of DNA Elements (ENCODE) Project in 2007 continues the pursuit of a systematic approach to catalogue and annotate genetic perturbation and its relation with disease susceptibility. The ENCODE Project is a logical step in augmenting the genomic sequence data produced by the Human Genome Project (HGP) with functional information. The various initiatives to isolate the causative gene associations with common diseases have met with understandable enthusiasm. These are, however, initial steps in better understanding human biology. To fully realize the potential of these powerful approaches, an appraisal of their ramifications will increasingly be in order. This article presents both the promise and challenges of genetic medicine in a broad perspective.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).