Studies on the Hormonal Control of Gastric Secretion

Authors

  • Mohamed F Wazna

DOI:

https://doi.org/10.5915/9-1-4464

Keywords:

Duodenal ulcer, gastric secretion

Abstract

The effects of serotonin lack and replacement on Histamine-stimulated gastric secretion from Heidenhain pouches of dogs were studied. Serotonin lack was produced either by reserpinedepletion or l-rnethyl-d-Iysergic acid butanolamide (UML 491)-antagonism. Serotonin lack significantly increased gastric acid secretion (P 0.02) and significantly reduced gastric pepsin secretion (P 0.05). Serotonin replacement by injecting 5-hydroxytryptophan significantly reduced gastric acid secretion (P 0.02) and significantly increased gastric pepsin secretion (P 0.05). These results indicate that serotonin is an inhibitor of gastric acid secretion and stimulator of pepsin secretion, and the mechanism of serotonin action must be, at least partyly, hormonal.

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Published

1978-04-01

Issue

Vol. 9 No. 1 (1978)

Section

Original Articles

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