Intravenous Ciprofloxacin Therapy in Respiratory Infections
Keywords:Fluoroquinolones, ciprofloxacin, infection, respiratory tract, sequential therapy
Of the quinolone class of antimicrobials, only intravenous (IV) ciprofloxacin is currently available for treatment of various bacterial infections. Pathogens causing pneumonia in otherwise healthy adult patients may differ from those found in elderly patients, nursing home residents, alcoholics, and in individuals with debilitating diseases. Nosocomial pneumonias typically involve Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. Aspiration pneumonia in the community most often involves anaerobes, but in the hospital S. aureus and Gram-negative organisms are commonly found. Based on these clinical and microbiological issues, a comparative evaluation of sequential IV and oral (PO) ciprofloxacin versus other antibiotics were reviewed and the results are summarized in this article. The focus is on the role of sequential intravenous/oral ciprofloxacin in the treatment of lower respiratory tract injection.
Presented at the lMA 24th Annual Convention Long Island, New York, July 1991
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