Fluoroquinolones in Skin and Soft-Tissue Infections

Authors

  • Suhail Raoof Department of Medciine Nassau County Medical Center East Meadow, New York United States of America

DOI:

https://doi.org/10.5915/24-1-15449

Keywords:

Antibiotics, quinolones, skin, infection

Abstract

DOI: http://dx.doi.org/10.5915/24-1-15449

Serious skin infections have usually been treated with one or more parenteral antibiotics. With the inception of the newer quinolones, this problem may be circumvented because this group of antibiotics is effective when taken orally. They penetrate the blister fluid inflammatory exudates. Their spectrum of activity encompasses the common Gram-negative organisms implicated in skin infections. They have varying degrees of activity against Gram-positive organisms including Staphylococcus and Streptococcus species. Their activity against anaerobes is poor. Ciprofloxacin has been used successfully in eradicating nasal colonization by methicillin resistant Staphylococcus aureus. Studies have shown that orally administered ciprofloxacin is as effective as intravenous cefotaxime in skin infections. Oral administration permit outpatient therapy and results in substantial cost reductions.

Presented at the IMA 24th Annual Convention, Long Island, New York, July 1991.

Author Biography

Suhail Raoof, Department of Medciine Nassau County Medical Center East Meadow, New York United States of America

M.D.

Department of Medciine
Nassau County Medical Center
East Meadow, New York
United States of America

References

Parish LC, Asper R: Systemic treatment of cutaneous infections. Am J Med. 1987;82(4A):227-9.

Perez-Ruvalcaba JA, Quintero-Perez NP, Morales-Reyes JJ et al. Double-blind comparison of ciprofloxacin with cefotaxime in the treatment of skin and skin structure infections. Am J Med. 1987;82(4A):242-6.

Hooper DC, Wolfson JS. Treatment of skin and soft-tissue infections with quinolone antimicrobial agents. In: Wolfson JS, Hooper DC, eds. Quinolone Antimicrobial Agents, Washington, DC: American Society of Microbiology; 1989:233-2.

Crump B, Wise R, Dent J. Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrob Agents Chemother.1983;24:784-6.

Daschner FD, Westenfelder M, Dalhoff A. Penetration of ciprofloxacin into kidney, fat, muscle, and skin tissue. Eur J Clio Microbiol. 1986;5:212-3.

Licitra CM, Brooks RG, Seiger BE. Clinical efficiency and levels of ciprofloxacin in tissue in patients with soft-tissue infection. Antimicrob Agents Chemother. 1987;31:805-7.

Lockley MR, Wise, R, Dent J. The pharmacokinetics and tissue penetration of ofloxacin. J Antimicrob Chemother. 1984;14:647-52.

Malmborg AS, Rannikko S. Enoxacin distribution in human tissues after multiple oral administration. J Antimicrob Chemother. 1988:27(Supplement B):57-60.

Wise R, Lockley R, Dent J et al. Pharmacokinetics and tissue penetration of enoxacin. Antimicrob Agents Chemother. 1984;26:17-9.

Webberley JM, Andrews JM, Ashby JP et al. Pharmacokinetics and tissue penetration of orally administered perfloxacin. Eur J Clin Microbiol. 1987;6:521-4.

Eron LJ. Fluoroquinolones in skin and skin structure infections. In: Sanders WE, Sanders CC, eds. Fluoroquinolones in the Treatment of Infectious Diseases. Glenview, IL: Physicians Scientists Publishing Co. Inc.;1990:61-9.

Smith SM, Eng RHK. Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemotber. 1985;27(5):688-91.

Sabater F, Mensa J, Domenech et al: Necrotizing external otitis treated with ciprofloxacin. A case report. J Laryngology Otology. 1988;102:606-7.

Andriole VT. Clinical overview of the newer quinolone antibacterial agents. In: Andriole VT, ed. The Quinolones. San Diego. CA: Academic Press Unlimited; 1988: 155-200.

Downloads

Published

1992-01-01

Issue

Vol. 24 No. 1 (1992)

Section

Review Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).