Fluoroquinolones in Skin and Soft-Tissue Infections


  • Suhail Raoof Department of Medciine Nassau County Medical Center East Meadow, New York United States of America




Antibiotics, quinolones, skin, infection


DOI: http://dx.doi.org/10.5915/24-1-15449

Serious skin infections have usually been treated with one or more parenteral antibiotics. With the inception of the newer quinolones, this problem may be circumvented because this group of antibiotics is effective when taken orally. They penetrate the blister fluid inflammatory exudates. Their spectrum of activity encompasses the common Gram-negative organisms implicated in skin infections. They have varying degrees of activity against Gram-positive organisms including Staphylococcus and Streptococcus species. Their activity against anaerobes is poor. Ciprofloxacin has been used successfully in eradicating nasal colonization by methicillin resistant Staphylococcus aureus. Studies have shown that orally administered ciprofloxacin is as effective as intravenous cefotaxime in skin infections. Oral administration permit outpatient therapy and results in substantial cost reductions.

Presented at the IMA 24th Annual Convention, Long Island, New York, July 1991.

Author Biography

Suhail Raoof, Department of Medciine Nassau County Medical Center East Meadow, New York United States of America


Department of Medciine
Nassau County Medical Center
East Meadow, New York
United States of America


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