Norfloxacin in Multiple Drug Resistant Typhoid Fever
Keywords:Salmonella typhi, Norfloxacin, Multiple Drug Resistance
This study was undertaken to assess the efficacy of Norfloxacin and oral quinolone in multiple drug resistant salmonella typhi infections in 45 patients. All these patients received 800 mg of Norfloxacin daily for a period of two weeks. All patients had positive blood cultures for salmonella typhi and 30 patients had, in addition, high and rising titers of TO and TH antigen (>1:160).
All patients responded from day 4 to day 10 of Norfloxacin therapy. A follow-up of one year did not reveal any relapse or a carrier state in the studied group. We recommend use of Norfloxacin in chloramphenicol resistant salmonella typhi infections.
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