Ciprofloxacin in Respiratory Tract Infections
Keywords:Quinolone, Ciprofloxacin, Respiratory Tract Infection
Of the quinolone class of antimicrobials, only oral ciprofloxacin is currently approved for respiratory indications. Ciprofloxacin has good tissue penetration and is active against most gram-negative and gram-positive pathogens, including Staplylococcus sp. It is, however, less effective against anaerobic bacteria and Streptococcus pneumoniae. The drug may be useful for managing bacterial exacerbations of COPD and for treating elderly patients with respiratory tract infections, including nosocomial pneumonias. Ciprofloxacin probably alters metabolism of theophylline and some antacids interfere with its absorption and antibacterial activity.
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