The Effect of Low Dose Aspirin on Placental Vascular Thrombosis in Pregnancies Complicated by Lupus Anticoagulant and Anticardiolipin Antibodies

  • Hameed Hadi Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine East Caroline University School of Medicine Greenville, NC
  • Susan Parks Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine East Caroline University School of Medicine Greenville, NC
  • James Finley
Keywords: Aspirin, Lupus Anticoagulant/Anticardiolipin Antibodies, Placental Vascular Thrombosis

Abstract

DOI: http://dx.doi.org/10.5915/22-4-14315

We followed six pregnant women with a history of pregnancy losses and presence of anticardiolipin antibodies. Two of these patients were also positive for lupus anticoagulant antibody. All patients were placed on low dose aspirin (81 mg/ day) from the first trimester onward. All women were delivered between 30-40 weeks of pregnancy because of evidence of intrauterine growth retardation and abnormal fetal surveillance tests. Microscopic examination of the placentas showed thrombi involving large and medium sized vessels in tertiary stem villi and prominent medial hyperplasia in small and medium sized arterioles. This study suggests that low dose aspirin therapy may ameliorate, but does not prevent, formation of placental vascular thrombi.

Author Biographies

Hameed Hadi, Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine East Caroline University School of Medicine Greenville, NC

M.D.

Department of Obstetrics and Gynecology
Division of Maternal-Fetal Medicine
East Caroline University School of Medicine
Greenville, NC

Susan Parks, Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine East Caroline University School of Medicine Greenville, NC

M.D.

Department of Obstetrics and Gynecology
Division of Maternal-Fetal Medicine
East Caroline University School of Medicine
Greenville, NC

James Finley
Department of Pathology
East Caroline University School of Medicine
Greenville, NC
Published
1990-10-01
Section
Original Articles