Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis
Urinary pepsinogen levels were determined in 314 patients with peptic ulcer and in 100 healthy controls to see if possible role in pathogenesis of peptic ulcer and to recognize elevated levels of urinary pepsinogen as a subclinical marker of ulcer diathesis. All patients studied were endoscopically proved to have peptic ulcer. Significantly elevated urinary pepsinogen levels were observed in patients with duodenal ulcer, pyloric ulcer and stomal ulcer, but increased level of urinary pepsinogen in gastric ulcer was not statistically significant when compared with controls. Sixteen percent of patients with duodenal ulcer had pepsinogen levels similar to the control group.
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