Intra-Arterial Chemotherapy in the Treatment of Malignant Brain Tumors

  • Jag Ahmed Devkota Eisenhower Regional Medical Ctr.
Keywords: Blood brain barrier disruption, intra-arterial chemotherapy, osmotic blood brain barrier modification, multi-agent chemotherapy, brain tumor treatment, technique of blood brain barrier disruption



The capillaries of the cerebral endothelium possesses a unique Blood Brain Barrier (BBB) property due to a continuous basement membrane, tight endothelium and lack of pinocytosis. This specialized barrier prevents passage of systemic chemotherapy into the brain tumor. To obtain an effective concentration of the chemotherapeutic agent, a transient reversible disruption of the barrier is required which is achieved by intra-arterial methotrexate and intravenous cytoxan infusion. The degree of disruption of the barrier was monitored by means of radio-isotope brain scan. The neuroradiologic special procedure and its role in the management of advanced brain tumor by modification of the BBB is presented.

Author Biography

Jag Ahmed Devkota, Eisenhower Regional Medical Ctr.
Staff Radiologist
Original Articles