Intra-Arterial Chemotherapy in the Treatment of Malignant Brain Tumors
DOI:
https://doi.org/10.5915/19-2-13009Keywords:
Blood brain barrier disruption, intra-arterial chemotherapy, osmotic blood brain barrier modification, multi-agent chemotherapy, brain tumor treatment, technique of blood brain barrier disruptionAbstract
DOI: http://dx.doi.org/10.5915/19-2-13009
The capillaries of the cerebral endothelium possesses a unique Blood Brain Barrier (BBB) property due to a continuous basement membrane, tight endothelium and lack of pinocytosis. This specialized barrier prevents passage of systemic chemotherapy into the brain tumor. To obtain an effective concentration of the chemotherapeutic agent, a transient reversible disruption of the barrier is required which is achieved by intra-arterial methotrexate and intravenous cytoxan infusion. The degree of disruption of the barrier was monitored by means of radio-isotope brain scan. The neuroradiologic special procedure and its role in the management of advanced brain tumor by modification of the BBB is presented.
Downloads
Published
1987-07-01
Issue
Section
Original Articles
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
