Glycosylated Hemoglobin and Protein Levels in Normal and Diabetic Pregnancies

Authors

  • Mohamed M Elseweidy Medical College of Georgia, Augusta, Georgia
  • Hossam E Fadel Medical College of Georgia, Augusta, GA, USA
  • Edathara C Abraham Medical College of Georgia, Augusta, Georgia

DOI:

https://doi.org/10.5915/17-2_3-12756

Keywords:

Glycosylation, Fetal hemoglobin, Glycosylated hemoglobin, Glycosylated protein, Diabetes mellitus, Normal pregnancy, Diabetic pregnancy

Abstract

DOI: http://dx.doi.org/10.5915/17-2_3-12756

The glycosylated fractions of hemoglobin i.e. Glycohemoglobin (GlycoHb) and of the plasma proteins i.e. Glycoprotein (GlycoPR) levels were quantitated using an affinity chromatographic technique in the cord and maternal blood of normal (Group I), White's Class A diabetic (Group II), and insulin-dependent diabetic (Group III) women. There was a significant increase of GlycoHb and GlycoPR levels in Group III compared lo Group I neonates. Maternal GlycoHb but not GlycoPR levels were significantly higher in Group Ill patients. Maternal and cord blood GlycoHb and GlycoPR levels in Class A diabetics were not different from those levels in the normal group. We conclude that the fetuses of insulin-dependent diabetic mothers are hyperglycemic in utero.

Author Biographies

Mohamed M Elseweidy, Medical College of Georgia, Augusta, Georgia

Ph.D.

Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Georgia

Hossam E Fadel, Medical College of Georgia, Augusta, GA, USA

Clinical professor, Ob/GYN Medical College of Georgia

M.D., F.A.C.O.G.

Edathara C Abraham, Medical College of Georgia, Augusta, Georgia

Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Georgia

Ph.D.

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Published

2004-07-01

Issue

Vol. 17 No. 2_3 (1985)

Section

Original Articles

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