Brain Seizure Threshold of Prenatally Nicotine-Treated Offspring

  • Ghazi M Al-Hachim Department of Pharmacology College of Medicine, Baghdad, Iraq
  • Faiza A Mohmood Department of Pharmacology College of Medicine, Baghdad, Iraq
Keywords: Nicotine, Pregancy, Seizures, Tobacco, Public Health

Abstract

DOI: http://dx.doi.org/10.5915/17-1-12718

The trimester of pregnancy through which nicotine may influence the postnatal development, has not been previously reported. Hence, 3 different doses of nicotine equivalent to 10 cigarettes (900 ug/kg). 20 cigarettes (1800 ug/kg) or 30 cigarettes (2700 ug/kg) were given daily subcutaneously (S.C.) during each trimester into 3 groups of pregnant mice. Their offspring were subjected to minimal electroshock seizure threshold (MEST) test. During the second trimester, the drug reduced the MEST of the offspring when they were I month old. However. during the third trimester, nicotine reduced their MEST when they were I and 2 months old. Thus, pregnant mothers are not recommended to be exposed to nicotine during the late stages of pregnancy.

Author Biographies

Ghazi M Al-Hachim, Department of Pharmacology College of Medicine, Baghdad, Iraq

Ph.D.

Department of Pharmacology

College of Medicine, Baghdad, Iraq

Faiza A Mohmood, Department of Pharmacology College of Medicine, Baghdad, Iraq
M. Sc.
Published
1985-01-12
Section
Original Articles