Radiopharmaceuticals for Pancreatic Imaging
Over the past few decades cancer of the pancreas has emerged as one of the most important neoplasias in human beings. It now accounts for approximately 20,000 deaths annually in the United States. Diseases of the pancreas are difficult to diagnose by standard clinical or medical imaging techniques. In spite of the introduction of the CT scanner and ultrasonography, there is a lack of suitable diagnostic agents for pancreatic carcinoma which is the most difficult abdominal tumor to diagnose and, in only 30% of autopsied cases, the clinical diagnosis was correct. As the existing diagnostic procedures confirm the pathological condition too late for proper treatment, the prognosis of pancreatic carcinoma is poor.
In 1929 acid dyes such as acid fuchsin, fast yellow fluorescein and methyl orange. and basic dyes such as basic fuchsin, methylene blue, rhodomin B. safarino and safrin extra bluish were used to measure pancreatic function, as these dyes concentrated moderately selectively in the pancreas.
In this paper, radioisotope labeled agents such as
35S-methionine,75Seselenomethionine, 11C-methionine radioiodine labeled paraiodo-phenyl alanine, 99mTc-labeled methionine, 131Cs-cesium acetate, etc. used to image the pancreas will be presented.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).