The Efficacy of Vitamin E in the Treatment of Tardive Dyskinesia: A Double-Blind Placebo Controlled Study

Authors

  • Mehmud Yucel Agargun Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey
  • Mecid Caliskan Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey
  • Melek Soner Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey
  • Fikret Aysal Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey
  • Latif Alpkan Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

DOI:

https://doi.org/10.5915/26-2-16367

Keywords:

Vitamin E, Antioxidant therapy, Tardive dyskinesia, Neuroleptic medication, Chronic schizophrenia

Abstract

DOI: http://dx.doi.org/10.5915/26-2-16367

Our aim in this study was to investigate the efficacy of vitamin E in the treatment of tardive dyskinesia in a group of chronic schizophrenic patients. Thirty-eight chronic schizophrenic inpatients with tardive dyskinesia were selected for a double-blind trial of Vitamin E versus placebo (Vitamin E: N=18). Tardive dyskinesia was rated by a blind-trained rater using the Abnormal Involuntary Movement Scale (AIMS) at baseline and after treatment. The AIMS scores in the Vitamin E cohort decreased significantly after treatment while the AJMS scores in the placebo cohort were not different after placebo. The results replicate the short-term effectiveness of Vitamin E in the treatment of tardive dyskinesia in a larger group of chronic schizophrenic patients.

Author Biographies

Mehmud Yucel Agargun, Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

MD

Bakirkoy Neuro-Psychiatric Hospital
Istanbul
Turkey

Mecid Caliskan, Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

MD

Bakirkoy Neuro-Psychiatric Hospital
Istanbul
Turkey

Melek Soner, Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

MD

Bakirkoy Neuro-Psychiatric Hospital
Istanbul
Turkey

Fikret Aysal, Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

MD

Bakirkoy Neuro-Psychiatric Hospital
Istanbul
Turkey

Latif Alpkan, Bakirkoy Neuro-Psychiatric Hospital Istanbul Turkey

MD

Bakirkoy Neuro-Psychiatric Hospital
Istanbul
Turkey

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Published

1996-04-01

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Section

Original Articles