The Efficacy of Vitamin E in the Treatment of Tardive Dyskinesia: A Double-Blind Placebo Controlled Study

Mehmud Yucel Agargun, Mecid Caliskan, Melek Soner, Fikret Aysal, Latif Alpkan



Our aim in this study was to investigate the efficacy of vitamin E in the treatment of tardive dyskinesia in a group of chronic schizophrenic patients. Thirty-eight chronic schizophrenic inpatients with tardive dyskinesia were selected for a double-blind trial of Vitamin E versus placebo (Vitamin E: N=18). Tardive dyskinesia was rated by a blind-trained rater using the Abnormal Involuntary Movement Scale (AIMS) at baseline and after treatment. The AIMS scores in the Vitamin E cohort decreased significantly after treatment while the AJMS scores in the placebo cohort were not different after placebo. The results replicate the short-term effectiveness of Vitamin E in the treatment of tardive dyskinesia in a larger group of chronic schizophrenic patients.


Vitamin E; Antioxidant therapy; Tardive dyskinesia; Neuroleptic medication; Chronic schizophrenia

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