Fluoroquinolones in Skin and Soft-Tissue Infections

Suhail Raoof

Abstract


DOI: http://dx.doi.org/10.5915/24-1-15449

Serious skin infections have usually been treated with one or more parenteral antibiotics. With the inception of the newer quinolones, this problem may be circumvented because this group of antibiotics is effective when taken orally. They penetrate the blister fluid inflammatory exudates. Their spectrum of activity encompasses the common Gram-negative organisms implicated in skin infections. They have varying degrees of activity against Gram-positive organisms including Staphylococcus and Streptococcus species. Their activity against anaerobes is poor. Ciprofloxacin has been used successfully in eradicating nasal colonization by methicillin resistant Staphylococcus aureus. Studies have shown that orally administered ciprofloxacin is as effective as intravenous cefotaxime in skin infections. Oral administration permit outpatient therapy and results in substantial cost reductions.

Presented at the IMA 24th Annual Convention, Long Island, New York, July 1991.


Keywords


Antibiotics; quinolones; skin; infection

Full Text:

PDF

References


Parish LC, Asper R: Systemic treatment of cutaneous infections. Am J Med. 1987;82(4A):227-9.

Perez-Ruvalcaba JA, Quintero-Perez NP, Morales-Reyes JJ et al. Double-blind comparison of ciprofloxacin with cefotaxime in the treatment of skin and skin structure infections. Am J Med. 1987;82(4A):242-6.

Hooper DC, Wolfson JS. Treatment of skin and soft-tissue infections with quinolone antimicrobial agents. In: Wolfson JS, Hooper DC, eds. Quinolone Antimicrobial Agents, Washington, DC: American Society of Microbiology; 1989:233-2.

Crump B, Wise R, Dent J. Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrob Agents Chemother.1983;24:784-6.

Daschner FD, Westenfelder M, Dalhoff A. Penetration of ciprofloxacin into kidney, fat, muscle, and skin tissue. Eur J Clio Microbiol. 1986;5:212-3.

Licitra CM, Brooks RG, Seiger BE. Clinical efficiency and levels of ciprofloxacin in tissue in patients with soft-tissue infection. Antimicrob Agents Chemother. 1987;31:805-7.

Lockley MR, Wise, R, Dent J. The pharmacokinetics and tissue penetration of ofloxacin. J Antimicrob Chemother. 1984;14:647-52.

Malmborg AS, Rannikko S. Enoxacin distribution in human tissues after multiple oral administration. J Antimicrob Chemother. 1988:27(Supplement B):57-60.

Wise R, Lockley R, Dent J et al. Pharmacokinetics and tissue penetration of enoxacin. Antimicrob Agents Chemother. 1984;26:17-9.

Webberley JM, Andrews JM, Ashby JP et al. Pharmacokinetics and tissue penetration of orally administered perfloxacin. Eur J Clin Microbiol. 1987;6:521-4.

Eron LJ. Fluoroquinolones in skin and skin structure infections. In: Sanders WE, Sanders CC, eds. Fluoroquinolones in the Treatment of Infectious Diseases. Glenview, IL: Physicians Scientists Publishing Co. Inc.;1990:61-9.

Smith SM, Eng RHK. Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemotber. 1985;27(5):688-91.

Sabater F, Mensa J, Domenech et al: Necrotizing external otitis treated with ciprofloxacin. A case report. J Laryngology Otology. 1988;102:606-7.

Andriole VT. Clinical overview of the newer quinolone antibacterial agents. In: Andriole VT, ed. The Quinolones. San Diego. CA: Academic Press Unlimited; 1988: 155-200.




DOI: http://dx.doi.org/10.5915/24-1-15449

Comments on this article

View all comments





Islamic Medical Association of North America (IMANA) | JIMA and IMANA on Twitter

 

Creative Commons License
This work by Work's author(s) is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.