Experience with Blood Brain Barrier Disruption in the Treatment of Malignant Brain Tumor
DOI:
https://doi.org/10.5915/17-2&3-12753Keywords:
Brain cancer, Chemotherapy, Oncology, MannitolAbstract
DOI: http://dx.doi.org/10.5915/17-2_3-12753
The blood-brain-barrier (BBB) seems to be a major factor in the paucity of chemotherapeutic agents entering the brain to be effective against the malignant brain tumor. Since systemic treatment with large doses of chemotherapeutic agents provide no benefit, a transient reversible osmotic opening of this barrier is necessary. Intra-arterial infusion of hyperosmolar mannitol into the cerebral tumor area disrupts the BBB and thus immediate intra-arterial infusion of multiple drugs enabled them to reach the tumor in a much higher concentration. This disruptive mechanism and mode of delivery of drug appeared to be the only currently available effective and dependable pathway.
Downloads
Published
1985-07-01
Issue
Section
Original Articles
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
